The Presence of Anti Thyroid and Anti Ovarian Auto-Antibodies in Familial Premature Ovarian Failure

Background Premature ovarian failure (POF) is a disorder of multi causal etiology. Autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in POF. The aim of this study was to identify the level of auto-antibodies in POF and familial POF patients. MaterialsAndMethods In this study, auto-antibodies including anti-ovarian antibody (AOA), anti thyroid peroxidase (TPO) and anti thyroglobulin (TG) antibodies were assessed in the sera of 43 cases with spontaneous POF including 12 cases affected by familial POF. The control samples were obtained from sera of 39 women with normal ovulatory or post menopause women. Results AOA were detected in 46.5% of the POF group, 41.7% of the familial POF group and 41% of the control group without significant statistical difference between the three groups. Thyroid peroxidase (TPO) antibody was found in 32.6% of the POF group, 41.6% of the familial POF group and 10.3% of the control group. Anti TPO was detected significantly high in both POF and familial POF groups (p